1.To temper or mix unduly; to make disproportionate; to change the due proportions of. (Obs.) "When... the humors in his body ben distempered."
2.To derange the functions of, whether bodily, mental, or spiritual; to disorder; to disease. "The imagination, when completely distempered, is the most incurable of all disordered faculties."
3.To deprive of temper or moderation; to disturb; to ruffle; to make disaffected, ill-humored, or malignant. "Distempered spirits."
4.To intoxicate. (R.) "The courtiers reeling, And the duke himself, I dare not say distempered, But kind, and in his tottering chair carousing."
5.(Paint.) To mix (colors) in the way of distemper; as, to distemper colors with size. (R.)