1.The act or process of operating; agency; the exertion of power, physical, mechanical, or moral. "The pain and sickness caused by manna are the effects of its operation on the stomach." "Speculative painting, without the assistance of manual operation, can never attain to perfection."
2.The method of working; mode of action.
3.That which is operated or accomplished; an effect brought about in accordance with a definite plan; as, military or naval operations.
4.Effect produced; influence. (Obs.) "The bards... had great operation on the vulgar."
5.(Math.) Something to be done; some transformation to be made upon quantities or mathematical objects, the transformation being indicated either by rules or symbols.
6.(Surg.) Any methodical action of the hand, or of the hand with instruments, on the human body, to produce a curative or remedial effect, as in amputation, etc.