Make a mess of, destroy or ruin. Synonyms: ball up, blow, bobble, bodge, bollix, bollix up, bollocks, bollocks up, botch, botch up, bumble, bungle, flub, fluff, foul up, fuck up, fumble, louse up, mess up, mishandle, muff, screw up, spoil. "The pianist screwed up the difficult passage in the second movement"